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Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models
GGGGCC (G(4)C(2)) repeat expansion in C9ORF72 is the most common genetic cause of ALS and FTD. An important issue is how repeat RNAs and their translation products—various dipeptide repeat (DPR) proteins—cause neurodegeneration. Drosophila has been widely used to model G(4)C(2) repeat RNA and DPR pr...
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| 出版年: | Trends Neurosci |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6015541/ https://ncbi.nlm.nih.gov/pubmed/29729808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tins.2018.04.002 |
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