Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate lymphoid cells (ILC2s) provided tissue-restricted T cell co-stimulation that...

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Veröffentlicht in:Immunity
Hauptverfasser: Halim, Timotheus Y.F., Rana, Batika M.J., Walker, Jennifer A., Kerscher, Bernhard, Knolle, Martin D., Jolin, Helen E., Serrao, Eva M., Haim-Vilmovsky, Liora, Teichmann, Sarah A., Rodewald, Hans-Reimer, Botto, Marina, Vyse, Timothy J., Fallon, Padraic G., Li, Zhi, Withers, David R., McKenzie, Andrew N.J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015114/
https://ncbi.nlm.nih.gov/pubmed/29907525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.05.003
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