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Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p

Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...

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Autori principali: Gasch, Audrey P., Huang, Mingxia, Metzner, Sandra, Botstein, David, Elledge, Stephen J., Brown, Patrick O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC60150/
https://ncbi.nlm.nih.gov/pubmed/11598186
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