ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair

DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an intricate signaling cascade referred to as the DNA damage response (DDR) to prevent such damage. The gene product ataxia telangiectasia and Rad3-related (ATR)...

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Bibliographic Details
Main Authors: Brown, Adam D., Sager, Brian W., Gorthi, Aparna, Tonapi, Sonal S., Brown, Eric J., Bishop, Alexander J. R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968013/
https://ncbi.nlm.nih.gov/pubmed/24675793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091222
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