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Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP

Natriuretic peptides (NPs) are important hormones that regulate multiple cellular functions including cardiovascular physiology. In the heart, two natriuretic peptide receptors NPR1 and NPR2 act as membrane guanylyl cyclases to produce 3′,5′-cyclic guanosine monophosphate (cGMP). Although both recep...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Subramanian, Hariharan, Froese, Alexander, Jönsson, Peter, Schmidt, Hannes, Gorelik, Julia, Nikolaev, Viacheslav O.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014982/
https://ncbi.nlm.nih.gov/pubmed/29934640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04891-5
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