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Glutathione deficiency sensitizes cultured embryonic mouse ovaries to benzo[a]pyrene-induced germ cell apoptosis

Mice lacking the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in glutathione (GSH) synthesis, have decreased tissue GSH. We previously showed that Gclm−/− embryos have increased sensitivity to the prenatal in vivo ovarian toxicity of the polycyclic aromatic hydrocar...

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Bibliografiske detaljer
Udgivet i:Toxicol Appl Pharmacol
Main Authors: Lim, Jinhwan, Luderer, Ulrike
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013410/
https://ncbi.nlm.nih.gov/pubmed/29800640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2018.05.024
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