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Glutathione deficiency sensitizes cultured embryonic mouse ovaries to benzo[a]pyrene-induced germ cell apoptosis
Mice lacking the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in glutathione (GSH) synthesis, have decreased tissue GSH. We previously showed that Gclm−/− embryos have increased sensitivity to the prenatal in vivo ovarian toxicity of the polycyclic aromatic hydrocar...
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| Publicado no: | Toxicol Appl Pharmacol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6013410/ https://ncbi.nlm.nih.gov/pubmed/29800640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2018.05.024 |
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