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Light-dependent cytoplasmic recruitment enhances the dynamic range of a nuclear import photoswitch

Cellular signal transduction is often regulated at multiple steps in order to achieve more complex logic or precise control of a pathway. For instance, some signaling mechanisms couple allosteric activation with localization to achieve high signal to noise. Here, we create a system for light activat...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Yumerefendi, Hayretin, Wang, Hui, Dickinson, Daniel J, Lerner, Andrew M, Malkus, Per, Goldstein, Bob, Hahn, Klaus, Kuhlman, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013380/
https://ncbi.nlm.nih.gov/pubmed/29446199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700681
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