DO “COPD SUBTYPES” REALLY EXIST?: Assessment of COPD Heterogeneity and Clustering Reproducibility in 17,154 Individuals Across Ten Independent Cohorts

BACKGROUND: COPD is a heterogeneous disease, but there is little consensus on specific definitions for COPD subtypes. Unsupervised clustering offers the promise of “unbiased” data-driven assessment of COPD heterogeneity. Multiple groups have identified COPD subtypes using cluster analysis, but there...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Castaldi, Peter J, Benet, Marta, Petersen, Hans, Rafaels, Nicholas, Finigan, James, Paoletti, Matteo, Boezen, H. Marike, Vonk, Judith M., Bowler, Russell, Pistolesi, Massimo, Puhan, Milo A., Anto, Josep, Wauters, Els, Lambrechts, Diether, Janssens, Wim, Bigazzi, Francesca, Camiciottoli, Gianna, Cho, Michael H, Hersh, Craig P, Barnes, Kathleen, Rennard, Stephen, Boorgula, Meher Preethi, Dy, Jennifer, Hansel, Nadia H, Crapo, James D, Tesfaigzi, Yohannes, Agusti, Alvar, Silverman, Edwin K, Garcia-Aymerich, Judith
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013053/
https://ncbi.nlm.nih.gov/pubmed/28637835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2016-209846
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