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A Hidden Mode of Action of Glycopeptide Antibiotics: Inhibition of Wall Teichoic Acid Biosynthesis

Glycopeptide antibiotics inhibit the peptidoglycan biosynthesis in Gram-positive bacteria by targeting lipid II. This prevents the recycling of bactoprenol phosphate, the lipid transporter that is shared by peptidoglycan and wall teichoic acid biosyntheses. In this study, we investigate the effects...

詳細記述

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書誌詳細
出版年:J Phys Chem B
主要な著者: Singh, Manmilan, Chang, James, Coffman, Lauryn, Kim, Sung Joon
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013045/
https://ncbi.nlm.nih.gov/pubmed/28368603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.7b00324
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