Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus

Solid-state NMR measurements performed on intact whole cells of S. aureus labeled selectively in vivo have established that des-N-methylleucyl oritavancin (which has antimicrobial activity) binds to the cell-wall peptidoglycan, even though removal of the terminal N-methylleucyl residue destroys the...

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Main Authors: Kim, Sung Joon, Cegelski, Lynette, Stueber, Dirk, Singh, Manmilan, Dietrich, Evelyne, Tanaka, Kelly S. E., Parr, Thomas R., Far, Adel Rafai, Schaefer, Jacob
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276640/
https://ncbi.nlm.nih.gov/pubmed/18258256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.031
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