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Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus
Solid-state NMR measurements performed on intact whole cells of S. aureus labeled selectively in vivo have established that des-N-methylleucyl oritavancin (which has antimicrobial activity) binds to the cell-wall peptidoglycan, even though removal of the terminal N-methylleucyl residue destroys the...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276640/ https://ncbi.nlm.nih.gov/pubmed/18258256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.031 |
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