DIPG-54. TREATMENT OF A PEDIATRIC PATIENT WITH AN H3.3 K27M MUTANT DIPG WITH ONC201, A SELECTIVE DRD2 ANTAGONIST

Although radiotherapy is the mainstay of treatment for children with diffuse intrinsic pontine gliomas (DIPG), fewer than 10% of patients survive past two years from diagnosis despite 30 years of clinical trials. ONC201 is an oral, selective DRD2 antagonist that induces p53-independent apoptosis and...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Suarez, Fernando, Stafford, James M, Tarapore, Rohinton, Oster, Wolfgang, Allen, Joshua E, Chi, Andrew S, Gardner, Sharon
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012976/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.147
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