IMMU-25. RADIO-IMMUNOTHERAPY USING THE IDO PATHWAY INHIBITOR INDOXIMOD FOR CHILDREN WITH NEWLY-DIAGNOSED DIPG

BACKGROUND: Indoximod is an IDO pathway inhibitor with a differentiated mechanism of action directly targeting immune cells to reverse the immune suppression generated by tumors. An ongoing phase-1b/2a study (NCT02502708) using indoximod in combination with temozolomide and/or re-irradiation for chi...

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Publicado en:Neuro Oncol
Main Authors: Johnson, Theodore S, Aguilera, Dolly, Al-Basheer, Ahmad, Castellino, Craig, Eaton, Bree R, Esiashvili, Natia, Foreman, Nicholas, Heger, Ian M, Kennedy, Eugene P, Link, Charles J, Martin, William, Ring, Eric, Sadek, Ramses F, Smith, Amy, Vahanian, Nicholas N, MacDonald, Tobey J, Munn, David H
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Abstracts
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012944/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.341
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