DIPG-22. A PHASE 1 TRIAL OF THE HISTONE DEACETYLASE INHIBITOR PANOBINOSTAT IN PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY DIFFUSE INTRINSIC PONTINE GLIOMA: A PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) STUDY

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood cancer with a median overall survival (OS) of 10 months and a post-progression survival (PPS) of 2–3 months. Panobinostat (LBH589) is a multi-histone deacetylase inhibitor with activity against preclinical models of DIPG. The...

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Publicado no:Neuro Oncol
Main Authors: Cooney, Tabitha, Onar-Thomas, Arzu, Huang, Jie, Lulla, Rishi, Fangusaro, Jason, Kramer, Kim, Baxter, Patricia, Fouladi, Maryam, Dunkel, Ira J, Warren, Katherine E, Monje, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012894/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.115
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