EAPH-14. MOLECULAR BIOLOGY AND PHASE I STUDY OF GM-CSF AND INTRATHECAL TRASTUZUMAB IN CHILDREN WITH RECURRENT POSTERIOR FOSSA EPENDYMOMA

BACKGROUND: Posterior fossa ependymoma (PF EPN) is a pediatric central nervous system malignancy that has poor outcome to standard therapeutic approaches. The majority of PF EPN tumors have increased HER2 expression. Trastuzumab is a monoclonal antibody that targets HER2, and sargramostim (GM-CSF) s...

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Publié dans:Neuro Oncol
Auteurs principaux: Dorris, Kathleen, Widener, Melissa, Amani, Vladimir, Donson, Andrew, Schissel, Debra, O’Neill, Brent, Hankinson, Todd, Handler, Michael, Macy, Margaret, Foreman, Nicholas
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012808/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.183
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