EPCT-18. PHASE 0/I STUDY OF GM-CSF AND INTRATHECAL TRASTUZUMAB IN CHILDREN WITH RECURRENT POSTERIOR FOSSA EPENDYMOMA

BACKGROUND: Posterior fossa ependymoma (PF EPN) is a pediatric central nervous system malignancy that has a poor outcome to standard therapeutic approaches. The majority of PF EPN tumors have increased HER2 expression. Trastuzumab is a monoclonal antibody that targets HER2, and sargramostim (GM-CSF)...

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Foilsithe in:Neuro Oncol
Main Authors: Dorris, Kathleen, Widener, Melissa, Amani, Vladimir, Donson, Andrew, Schissel, Debra, Carson, Jessica, Mettetal, Ashley, Ramirez, Dominique, Gustafson, Daniel, Hankinson, Todd, Handler, Michael, Macy, Margaret, Foreman, Nicholas
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Early Phase Clinical Trials
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715093/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.140
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