ATRT-35. SMARCB1-DEFICIENT TUMORS ACTIVATE BOTH INNATE AND ADAPTIVE IMMUNE RESPONSES AND ARE SUSCEPTIBLE TO CHECKPOINT BLOCKADE AND TLR3 ACTIVATION

In order to evaluate the immune infiltrate of AT/RT, we conducted a combined immunohistochemical, multiparametric flow cytometry and transcriptomic analysis of a series of 49 human AT/RT. This revealed substantial heterogeneity, with some subgroups of AT/RT showing a prominent immune infiltrate. In...

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Published in:Neuro Oncol
Main Authors: Leruste, Amaury, Caudana, Pamela, Tauziede-Espariat, Arnault, Han, Zhi-Yan, Ramos, Rodrigo N, Nikolic, Jovan, Tosello, Jimena, Brohard, Solene, Andrianteranagna, Mamy, Chauvin, Céline, Masliah-Planchon, Julien, Sedlick, Christine, Coulomb, Aurore, Galmiche-Rolland, Louise, Ranchere, Dominique, Benaroch, Philippe, Waterfall, Joshua J, Delattre, Olivier, Piaggio, Eliane, Bourdeaut, Franck
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012020/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.032
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