SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

We describe here the identification and properties of SCH-C (SCH 351125), a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor. SCH-C, an oxime–piperidine compound, is a specific CCR5 antagonist as determined in multiple receptor binding and signal transduction assays. This compound spe...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, Endres, Michael, Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Tagat, Jayaram R., McCombie, Stuart, Cox, Kathleen, Fawzi, Ahmad B., Chou, Chuan-Chu, Pugliese-Sivo, Catherine, Davies, Liza, Moreno, Mary E., Ho, David D., Trkola, Alexandra, Stoddart, Cheryl A., Moore, John P., Reyes, Gregory R., Baroudy, Bahige M.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2001
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60120/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606733/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.221375398
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