SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

We describe here the identification and properties of SCH-C (SCH 351125), a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor. SCH-C, an oxime–piperidine compound, is a specific CCR5 antagonist as determined in multiple receptor binding and signal transduction assays. This compound spe...

Celý popis

Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, Endres, Michael, Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Tagat, Jayaram R., McCombie, Stuart, Cox, Kathleen, Fawzi, Ahmad B., Chou, Chuan-Chu, Pugliese-Sivo, Catherine, Davies, Liza, Moreno, Mary E., Ho, David D., Trkola, Alexandra, Stoddart, Cheryl A., Moore, John P., Reyes, Gregory R., Baroudy, Bahige M.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2001
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60120/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606733/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.221375398
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!