Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America

The mechanistic basis for chloroquine resistance (CQR) in Plasmodium falciparum recently has been linked to the polymorphic gene pfcrt. Alleles associated with CQR in natural parasite isolates harbor threonine (T), as opposed to lysine (K) at amino acid 76. P. falciparum CQR strains of African and S...

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Detalhes bibliográficos
Main Authors: Mehlotra, Rajeev K., Fujioka, Hisashi, Roepe, Paul D., Janneh, Omar, Ursos, Lyann M. B., Jacobs-Lorena, Vanessa, McNamara, David T., Bockarie, Moses J., Kazura, James W., Kyle, Dennis E., Fidock, David A., Zimmerman, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC60115/
https://ncbi.nlm.nih.gov/pubmed/11675500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221440898
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