Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea

BACKGROUND: Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous studies have shown that microsatellite (MS) haplotype variation can be used to...

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Détails bibliographiques
Auteurs principaux: DaRe, Jeana T, Mehlotra, Rajeev K, Michon, Pascal, Mueller, Ivo, Reeder, John, Sharma, Yagya D, Stoneking, Mark, Zimmerman, Peter A
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2007
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838424/
https://ncbi.nlm.nih.gov/pubmed/17376240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-6-34
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