In vitro and in vivo evaluation of hypothermia on pharmacokinetics and pharmacodynamics of nimodipine in rabbits

OBJECTIVE: To investigate the effect of hypothermia on the pharmacokinetics and pharmacodynamics of nimodipine in rabbits using in vivo and in vitro methods. METHODS: Five healthy New Zealand rabbits received a single dose of nimodipine (0.5 mg/kg) intravenously under normothermic and hypothermic co...

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Detalhes bibliográficos
Publicado no:J Int Med Res
Main Authors: Fei, Yu-xing, Zhang, Tian-hong, Zhao, Jing, Ren, He, Du, Ya-nan, Yu, Chun-ling, Wang, Qiang, Li, Shu, Ren, Ting-lin, Jian, Qiang, Fei, Shu-yang, Zhang, Zhen-qing, Zhang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2017
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011315/
https://ncbi.nlm.nih.gov/pubmed/28851258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0300060517720056
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