Cysteine boosters the evolutionary adaptation to CoCl(2) mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

BACKGROUND: Ovarian cancer is the second most common gynaecologic malignancy and the most common cause of death from gynaecologic cancer, especially due to diagnosis at an advanced stage, when a cure is rare. As ovarian tumour grows, cancer cells are exposed to regions of hypoxia. Hypoxia is known t...

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Udgivet i:BMC Evol Biol
Main Authors: Nunes, Sofia C., Lopes-Coelho, Filipa, Gouveia-Fernandes, Sofia, Ramos, Cristiano, Pereira, Sofia A., Serpa, Jacinta
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011206/
https://ncbi.nlm.nih.gov/pubmed/29921232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-018-1214-1
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