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Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task

A dual regulation of contraction operates in both skeletal and cardiac muscles. The first mechanism, based on Ca(2+)-dependent structural changes of the regulatory proteins in the thin filament, makes the actin sites available for binding of the myosin motors. The second recruits the myosin heads fr...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Physiol
Prif Awduron: Piazzesi, Gabriella, Caremani, Marco, Linari, Marco, Reconditi, Massimo, Lombardi, Vincenzo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010558/
https://ncbi.nlm.nih.gov/pubmed/29962967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00736
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