The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus

Activation of the DNA-dependent innate immune pathway plays a pivotal role in the host defense against poxvirus. Cyclic GMP-AMP synthase (cGAS) is a key cytosolic DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which triggers stimulator of interferon genes (STING),...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Cheng, Wen-Yu, He, Xiao-Bing, Jia, Huai-Jie, Chen, Guo-Hua, Jin, Qi-Wang, Long, Zhao-Lin, Jing, Zhi-Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010520/
https://ncbi.nlm.nih.gov/pubmed/29963044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01297
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