Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate cancer using the spatial transcriptomics (ST) technology. Utilizing a novel approach for deconvolution, we analyze the...

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Publicado en:Nat Commun
Autores principales: Berglund, Emelie, Maaskola, Jonas, Schultz, Niklas, Friedrich, Stefanie, Marklund, Maja, Bergenstråhle, Joseph, Tarish, Firas, Tanoglidi, Anna, Vickovic, Sanja, Larsson, Ludvig, Salmén, Fredrik, Ogris, Christoph, Wallenborg, Karolina, Lagergren, Jens, Ståhl, Patrik, Sonnhammer, Erik, Helleday, Thomas, Lundeberg, Joakim
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010471/
https://ncbi.nlm.nih.gov/pubmed/29925878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04724-5
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