PEGylation of polypropylenimine dendrimers: effects on cytotoxicity, DNA condensation, gene delivery and expression in cancer cells

Diaminobutyric polypropylenimine (DAB) dendrimers have been shown to be highly efficient non-viral gene delivery systems for cancer therapy. However, their cytotoxicity currently limits their applications. To overcome this issue, PEGylation of DAB dendrimer, using various PEG molecular weights and d...

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Published in:Sci Rep
Main Authors: Somani, Sukrut, Laskar, Partha, Altwaijry, Najla, Kewcharoenvong, Paphitchaya, Irving, Craig, Robb, Gillian, Pickard, Benjamin S., Dufès, Christine
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010408/
https://ncbi.nlm.nih.gov/pubmed/29925967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27400-6
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