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A transgenic mouse for imaging activity-dependent dynamics of endogenous Arc mRNA in live neurons

Localized translation plays a crucial role in synaptic plasticity and memory consolidation. However, it has not been possible to follow the dynamics of memory-associated mRNAs in living neurons in response to neuronal activity in real time. We have generated a novel mouse model where the endogenous...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Das, Sulagna, Moon, Hyungseok C., Singer, Robert H., Park, Hye Yoon
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010337/
https://ncbi.nlm.nih.gov/pubmed/29938222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar3448
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