Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM

CD40 is a member of the tumor necrosis factor receptor superfamily, expressed on a wide range of cell types including B cells, macrophages, and dendritic cells. CD40 is the receptor for CD40 ligand (CD40L), a molecule predominantly expressed by activated CD4(+) T cells. CD40/CD40L interaction induce...

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Autors principals: Ferrari, Simona, Giliani, Silvia, Insalaco, Antonella, Al-Ghonaium, Abdulaziz, Soresina, Anna R., Loubser, Michael, Avanzini, Maria A., Marconi, Massimo, Badolato, Raffaele, Ugazio, Alberto G., Levy, Yves, Catalan, Nadia, Durandy, Anne, Tbakhi, Abdelghani, Notarangelo, Luigi D., Plebani, Alessandro
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC60102/
https://ncbi.nlm.nih.gov/pubmed/11675497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221456898
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