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Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations
Rab5 is a small GTPase and a key regulator in early endosomal trafficking. Rab5 and its effectors are involved in a large number of infectious diseases and certain types of cancer. We performed µs atomistic molecular dynamics simulations of inactive and active full-length Rab5 anchored to a complex...
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| Publicado en: | J Enzyme Inhib Med Chem |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6010109/ https://ncbi.nlm.nih.gov/pubmed/28090783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1260564 |
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