Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors

A series of curcumin inspired sulfonamide derivatives was prepared from various chalcones and 4-sulfamoyl benzaldehyde via Claisen–Schmidt condensation. All new compounds were assayed as inhibitors of four human isoforms of the metalloenzyme carbonic anhydrase (hCA, EC 4.2.1.1) isoforms hCA I, II, I...

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Publicado en:J Enzyme Inhib Med Chem
Autores principales: Ramya, P. V. Sri, Angapelly, Srinivas, Angeli, Andrea, Digwal, Chander Singh, Arifuddin, Mohammed, Babu, Bathini Nagendra, Supuran, Claudiu T., Kamal, Ahmed
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010064/
https://ncbi.nlm.nih.gov/pubmed/28965419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1380638
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