Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549

Novel halogenated purines and pseudopurines with diverse aryl-substituted 1,2,3-triazoles were prepared. While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit unselective activity on pancreatic adenocarcinoma cells CFPAC-1,1-(p-...

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Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Bistrović, Andrea, Grbčić, Petra, Harej, Anja, Sedić, Mirela, Kraljević-Pavelić, Sandra, Koštrun, Sanja, Plavec, Janez, Makuc, Damjan, Raić-Malić, Silvana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009932/
https://ncbi.nlm.nih.gov/pubmed/29271659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1414807
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