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Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators

Four human (h) carbonic anhydrase isoforms (CA, EC 4.2.1.1), hCA I, II, IV, and VII, were investigated for their activation profile with piperazines belonging to various classes, such as N-aryl-, N-alkyl-, N-acyl-piperazines as well as 2,4-disubstituted derivatives. As the activation mechanism invol...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Angeli, Andrea, Chiaramonte, Niccolò, Manetti, Dina, Romanelli, Maria Novella, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009915/
https://ncbi.nlm.nih.gov/pubmed/29280407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1417277
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