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Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrases by chiral N-(biarylsulfonyl)-phosphonic acids

A series of nanomolar phosphonate matrix metalloproteinase (MPP) inhibitors was tested for inhibitory activity against a panel of selected human carbonic anhydrase (CA, EC 4.2.1.1) isozymes, covering the cancer-associated CA IX and XII. None of the reported sulfonyl and sulfonylamino-derivatives sen...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Enzyme Inhib Med Chem
Κύριοι συγγραφείς: Luisi, Grazia, Angelini, Guido, Gasbarri, Carla, Laghezza, Antonio, Agamennone, Mariangela, Loiodice, Fulvio, Supuran, Claudiu T., Campestre, Cristina, Tortorella, Paolo
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Taylor & Francis 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009896/
https://ncbi.nlm.nih.gov/pubmed/28948845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1378192
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