Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles

A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar range. Preferential inhibitory potency agains...

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Publicat a:J Enzyme Inhib Med Chem
Autors principals: Nocentini, Alessio, Cadoni, Roberta, Dumy, Pascal, Supuran, Claudiu T., Winum, Jean-Yves
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2017
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009872/
https://ncbi.nlm.nih.gov/pubmed/29278948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1414808
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