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Viral attenuation by engineered protein fragmentation
A possible but untested method of viral attenuation is protein fragmentation, engineering wild-type proteins as two or more peptides that self-assemble after translation. Here, the bacteriophage T7 was engineered to encode its essential RNA polymerase as two peptides. Initial fitness was profoundly...
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| Publicado no: | Virus Evol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6009699/ https://ncbi.nlm.nih.gov/pubmed/29942657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ve/vey017 |
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