Dicer cleaves 5′-extended microRNA precursors originating from RNA polymerase II transcription start sites

MicroRNAs (miRNAs) are approximately 22 nucleotide (nt) long and play important roles in post-transcriptional regulation in both plants and animals. In animals, precursor (pre-) miRNAs are ∼70 nt hairpins produced by Drosha cleavage of long primary (pri-) miRNAs in the nucleus. Exportin-5 (XPO5) tra...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Sheng, Peike, Fields, Christopher, Aadland, Kelsey, Wei, Tianqi, Kolaczkowski, Oralia, Gu, Tongjun, Kolaczkowski, Bryan, Xie, Mingyi
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Nucleic Acid Enzymes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009592/
https://ncbi.nlm.nih.gov/pubmed/29746670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky306
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