Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has been considered as an anticancer target using specific chemical inhibitors. The nitroimidazoles DTP338 and DTP348 have been shown to inhibit CA IX in nanomolar range in vitro and red...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Enzyme Inhib Med Chem
Κύριοι συγγραφείς: Aspatwar, Ashok, Becker, Holger M., Parvathaneni, Nanda Kumar, Hammaren, Milka, Svorjova, Aleksandra, Barker, Harlan, Supuran, Claudiu T., Dubois, Ludwig, Lambin, Philippe, Parikka, Mataleena, Parkkila, Seppo, Winum, Jean-Yves
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Taylor & Francis 2018
Θέματα:
Research Paper
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009478/
https://ncbi.nlm.nih.gov/pubmed/29909747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1482285
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