Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has been considered as an anticancer target using specific chemical inhibitors. The nitroimidazoles DTP338 and DTP348 have been shown to inhibit CA IX in nanomolar range in vitro and red...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Enzyme Inhib Med Chem
Päätekijät: Aspatwar, Ashok, Becker, Holger M., Parvathaneni, Nanda Kumar, Hammaren, Milka, Svorjova, Aleksandra, Barker, Harlan, Supuran, Claudiu T., Dubois, Ludwig, Lambin, Philippe, Parikka, Mataleena, Parkkila, Seppo, Winum, Jean-Yves
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2018
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009478/
https://ncbi.nlm.nih.gov/pubmed/29909747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1482285
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia