Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features

Members of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. The sequences and crystal structures of three Tcl1 proteins were analyzed in orde...

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Veröffentlicht in:ScientificWorldJournal
Hauptverfasser: Petock, John M., Torshin, Ivan Y., Wang, Yuan-Fang, Du Bois, Garrett C., Croce, Carlo M., Harrison, Robert W., Weber, Irene T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: TheScientificWorldJOURNAL 2002
Schlagworte:
Mini-Review Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009430/
https://ncbi.nlm.nih.gov/pubmed/12920316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1100/tsw.2002.826
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