Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O(6)- methylguanine-DNA methyltransferase

O(6)-methylguanine (O(6)mG) is a potent mutagenic and procarcinogenic DNA lesion. Organisms have evolved with a DNA repair mechanism that largely ameliorates the deleterious effects of O(6)mG through a direct reversal mechanism by a protein termed O(6)-methylguanine-DNA methyltransferase (MGMT). How...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Zhou, Zi-Qiang, Manguino, Diwi, Kewitt, Kristen, Intano, Gabriel W., McMahan, C. Alex, Herbert, Damon C., Hanes, Martha, Reddick, Robert, Ikeno, Yuji, Walter, Christi A.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60094/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.221232998
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