Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O(6)- methylguanine-DNA methyltransferase

O(6)-methylguanine (O(6)mG) is a potent mutagenic and procarcinogenic DNA lesion. Organisms have evolved with a DNA repair mechanism that largely ameliorates the deleterious effects of O(6)mG through a direct reversal mechanism by a protein termed O(6)-methylguanine-DNA methyltransferase (MGMT). How...

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Main Authors: Zhou, Zi-Qiang, Manguino, Diwi, Kewitt, Kristen, Intano, Gabriel W., McMahan, C. Alex, Herbert, Damon C., Hanes, Martha, Reddick, Robert, Ikeno, Yuji, Walter, Christi A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC60094/
https://ncbi.nlm.nih.gov/pubmed/11606727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221232998
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