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Allele-Specific Conditional Destabilization of Glutamine Repeat mRNAs

Several late-onset neurological diseases are caused by the inheritance of an expanded CAG repeat coding for polyglutamine. To date there is no effective means of halting the progression of these diseases, and their underlying molecular mechanisms remain a mystery. Strategies designed to specifically...

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Bibliografiske detaljer
Udgivet i:Gene Expr
Main Authors: Crouse, Andrew B., Detloff, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: Cognizant Communication Corporation 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009115/
https://ncbi.nlm.nih.gov/pubmed/16128004
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