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Allele-Specific Conditional Destabilization of Glutamine Repeat mRNAs

Several late-onset neurological diseases are caused by the inheritance of an expanded CAG repeat coding for polyglutamine. To date there is no effective means of halting the progression of these diseases, and their underlying molecular mechanisms remain a mystery. Strategies designed to specifically...

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Bibliografski detalji
Izdano u:Gene Expr
Glavni autori: Crouse, Andrew B., Detloff, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: Cognizant Communication Corporation 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009115/
https://ncbi.nlm.nih.gov/pubmed/16128004
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