Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer

BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent. METHODS: We used...

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Udgivet i:Br J Cancer
Main Authors: Neumeyer, Sonja, Banbury, Barbara L., Arndt, Volker, Berndt, Sonja I., Bezieau, Stephane, Bien, Stephanie A., Buchanan, Dan D., Butterbach, Katja, Caan, Bette J., Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chanock, Stephen J., Dai, James Y., Gallinger, Steven, Giovannucci, Edward L., Giles, Graham G., Grady, William M., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Li, Jenkins, Mark A., Joshi, Amit, Larsson, Susanna C., Le Marchand, Loic, Lindblom, Annika, Moreno, Victor, Lemire, Mathieu, Li, Li, Lin, Yi, Offit, Kenneth, Newcomb, Polly A., Pharaoh, Paul D., Potter, John D., Qi, Lihong, Rennert, Gad, Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Song, Mingyang, Ulrich, Cornelia M., Win, Aung K., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Gruber, Stephen B., Brenner, Hermann, Peters, Ulrike, Chang-Claude, Jenny
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008474/
https://ncbi.nlm.nih.gov/pubmed/29795306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0108-8
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