Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair

Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Chen, Yu-An, Shih, Hua-Wei, Lin, Yi-Chun, Hsu, Hui-Ying, Wu, Tsu-Fang, Tsai, Chen-Han, Wu, Chia-Lin, Wu, Hui-Yu, Hsieh, Jer-Tsong, Tang, Chih-Hsin, Lai, Chih-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008406/
https://ncbi.nlm.nih.gov/pubmed/29950990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00600
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