Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division

BACKGROUND: Chromosomal instability (CIN) is a common trait of cancer characterised by the continuous gain and loss of chromosomes during mitosis. Excessive levels of CIN can suppress tumour growth, providing a possible therapeutic strategy. The Mps1/TTK kinase has been one of the prime targets to e...

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Vydáno v:Br J Cancer
Hlavní autoři: Maia, Ana Rita R., Linder, Simon, Song, Ji-Ying, Vaarting, Chantal, Boon, Ute, Pritchard, Colin E. J., Velds, Arno, Huijbers, Ivo J., van Tellingen, Olaf, Jonkers, Jos, Medema, René H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008333/
https://ncbi.nlm.nih.gov/pubmed/29736010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0081-2
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