DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 is...

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Publicado no:Nat Commun
Main Authors: Kular, Lara, Liu, Yun, Ruhrmann, Sabrina, Zheleznyakova, Galina, Marabita, Francesco, Gomez-Cabrero, David, James, Tojo, Ewing, Ewoud, Lindén, Magdalena, Górnikiewicz, Bartosz, Aeinehband, Shahin, Stridh, Pernilla, Link, Jenny, Andlauer, Till F. M., Gasperi, Christiane, Wiendl, Heinz, Zipp, Frauke, Gold, Ralf, Tackenberg, Björn, Weber, Frank, Hemmer, Bernhard, Strauch, Konstantin, Heilmann-Heimbach, Stefanie, Rawal, Rajesh, Schminke, Ulf, Schmidt, Carsten O., Kacprowski, Tim, Franke, Andre, Laudes, Matthias, Dilthey, Alexander T., Celius, Elisabeth G., Søndergaard, Helle B., Tegnér, Jesper, Harbo, Hanne F., Oturai, Annette B., Olafsson, Sigurgeir, Eggertsson, Hannes P., Halldorsson, Bjarni V., Hjaltason, Haukur, Olafsson, Elias, Jonsdottir, Ingileif, Stefansson, Kari, Olsson, Tomas, Piehl, Fredrik, Ekström, Tomas J., Kockum, Ingrid, Feinberg, Andrew P., Jagodic, Maja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008330/
https://ncbi.nlm.nih.gov/pubmed/29921915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04732-5
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