Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction

Homocyst(e)ine (Hcy) inhibits the expression of the antioxidant enzyme cellular glutathione peroxidase (GPx-1) in vitro and in vivo, which can lead to an increase in reactive oxygen species that inactivate NO and promote endothelial dysfunction. In this study, we tested the hypothesis that overexpre...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Weiss, Norbert, Zhang, Ying-Yi, Heydrick, Stanley, Bierl, Charlene, Loscalzo, Joseph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60083/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606774/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.231428998
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