FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

BACKGROUND & AIMS: Hepatic encephalopathy is a serious neurologic complication of acute and chronic liver diseases. We previously showed that aberrant bile acid signaling contributes to the development of hepatic encephalopathy via farnesoid X receptor (FXR)-mediated mechanisms in neurons. In th...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Mol Gastroenterol Hepatol
Main Authors: McMillin, Matthew, Grant, Stephanie, Frampton, Gabriel, Petrescu, Anca D., Kain, Jessica, Williams, Elaina, Haines, Rebecca, Canady, Lauren, DeMorrow, Sharon
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008252/
https://ncbi.nlm.nih.gov/pubmed/29928671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.02.008
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